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Cyclization of Fungal Nonribosomal Peptides by a Terminal Condensation-Like Domain

Cyclization of linear peptidyl precursors produced by nonribosomal peptide synthetases (NRPSs) is an important step in the biosynthesis of bioactive cyclic peptides. Whereas bacterial NRPSs use thioesterase (TE) domains to perform the cyclization, fungal NRPSs have apparently evolved to use a differ...

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Detalhes bibliográficos
Main Authors: Gao, Xue, Haynes, Stuart W., Ames, Brian D., Wang, Peng, Vien, Linda P., Walsh, Christopher T., Tang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505271/
https://ncbi.nlm.nih.gov/pubmed/22902615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1047
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