Molecular requirements for inhibition of the chemokine receptor CCR8 – probe-dependent allosteric interactions

BACKGROUND AND PURPOSE: Here we present a novel series of CCR8 antagonists based on a naphthalene-sulfonamide structure. This structure differs from the predominant pharmacophore for most small-molecule CC-chemokine receptor antagonists, which in fact activate CCR8, suggesting that CCR8 inhibition r...

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Main Authors: Rummel, PC, Arfelt, KN, Baumann, L, Jenkins, TJ, Thiele, S, Lüttichau, HR, Johnsen, A, Pease, J, Ghosh, S, Kolbeck, R, Rosenkilde, MM
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2012
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504988/
https://ncbi.nlm.nih.gov/pubmed/22708643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02076.x
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