Inhibition of the Ethanol-induced Potentiation of α1 Glycine Receptor by a Small Peptide That Interferes with Gβγ Binding

Previous studies indicate that ethanol can modulate glycine receptors (GlyR), in part, through Gβγ interaction with basic residues in the intracellular loop. In this study, we show that a seven-amino acid peptide (RQH(C7)), which has the primary structure of a motif in the large intracellular loop o...

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Main Authors: San Martin, Loreto, Cerda, Fabian, Jimenez, Veronica, Fuentealba, Jorge, Muñoz, Braulio, Aguayo, Luis G., Guzman, Leonardo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504784/
https://ncbi.nlm.nih.gov/pubmed/23035114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.393603
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