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Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide That Interferes with Gβγ Binding

The large intracellular loop (IL) of the glycine receptor (GlyR) interacts with various signaling proteins and plays a fundamental role in trafficking and regulation of several receptor properties, including a direct interaction with Gβγ. In the present study, we found that mutation of basic residue...

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Main Authors: Guzman, Leonardo, Moraga-Cid, Gustavo, Avila, Ariel, Figueroa, Maximiliano, Yevenes, Gonzalo E., Fuentealba, Jorge, Aguayo, Luis G.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784719/
https://ncbi.nlm.nih.gov/pubmed/19773530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160440
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