Evidence for α-Helices in the Large Intracellular Domain Mediating Modulation of the α1-Glycine Receptor by Ethanol and Gβγ

The α1-subunit containing glycine receptors (GlyRs) is potentiated by ethanol, in part, by intracellular Gβγ actions. Previous studies have suggested that molecular requirements in the large intracellular domain are involved; however, the lack of structural data about this region has made it difficu...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Burgos, Carlos F., Castro, Patricio A., Mariqueo, Trinidad, Bunster, Marta, Guzmán, Leonardo, Aguayo, Luis G.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2015
Subjects:
Neuropharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279101/
https://ncbi.nlm.nih.gov/pubmed/25339760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.217976
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