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Impact of Recovery from Desensitization on Acid-sensing Ion Channel-1a (ASIC1a) Current and Response to High Frequency Stimulation

ASIC1a is a neuronal sodium channel activated by external H(+) ions. To date, all the characterization of ASIC1a has been conducted applying long H(+) stimuli lasting several seconds. Such experimental protocols weaken and even silence ASIC1a currents to repetitive stimulation. In this work, we exam...

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Autors principals: Li, Tianbo, Yang, Youshan, Canessa, Cecilia M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504781/
https://ncbi.nlm.nih.gov/pubmed/23048040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.418400
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