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Extracellular Chloride Modulates the Desensitization Kinetics of Acid-sensing Ion Channel 1a (ASIC1a)
Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. The recent crystallization of ASIC1a identified potential binding sites for Cl(−) in the extracellular domain that are highly conserved between ASIC isoforms. However, the significance of Cl(−) binding is unknown....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878506/ https://ncbi.nlm.nih.gov/pubmed/20385551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091561 |
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