Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition

Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl(−)-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We previously found that anions modulate ASIC1a gating via these sites. Here w...

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Bibliographic Details
Main Authors: Kusama, Nobuyoshi, Gautam, Mamta, Harding, Anne Marie S., Snyder, Peter M., Benson, Christopher J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543573/
https://ncbi.nlm.nih.gov/pubmed/23135698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00216.2012
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