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Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition
Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl(−)-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We previously found that anions modulate ASIC1a gating via these sites. Here w...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3543573/ https://ncbi.nlm.nih.gov/pubmed/23135698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00216.2012 |
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