Loss of naïve T-cells and repertoire constriction predict poor response to vaccination in old primates

Aging is usually accompanied by diminished immune protection upon infection or vaccination. While aging results in well-characterized changes in the T-cell compartment of long-lived, outbred, and pathogen-exposed organisms, their relevance for primary antigen responses remain unclear. Therefore, it...

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Detalhes bibliográficos
Main Authors: Čičin-Šain, Luka, Smyk-Paerson, Sue, Currier, Noreen, Byrd, Laura, Koudelka, Caroline, Robinson, Tammie, Swarbrick, Gwendolyn, Tackitt, Shane, Legasse, Alfred, Fischer, Miranda, Nikolich-Zugich, Dragana, Park, Byung, Hobbs, Theodore, Doane, Cynthia J., Mori, Motomi, Axthelm, Michael T., Lewinsohn, Deborah A., Nikolich-Žugich, Janko
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504654/
https://ncbi.nlm.nih.gov/pubmed/20483749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904193
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