Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates

The loss of naïve T cells is a hallmark of immune aging. Although thymic involution is a primary driver of this naïve T cell loss, less is known about the contribution of other mechanisms to the depletion of naïve T cells in aging primates. We examined the role of homeostatic cycling and proliferati...

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Bibliographic Details
Main Authors: Čičin-Šain, Luka, Messaoudi, Ilhem, Park, Byung, Currier, Noreen, Planer, Shannon, Fischer, Miranda, Tackitt, Shane, Nikolich-Žugich, Dragana, Legasse, Alfred, Axthelm, Michael K., Picker, Louis J., Mori, Motomi, Nikolich-Žugich, Janko
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148405/
https://ncbi.nlm.nih.gov/pubmed/18056811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705905104
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