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Transcriptional Silencing of Transposons by Piwi and Maelstrom and Its Impact on Chromatin State and Gene Expression

Eukaryotic genomes are colonized by transposons whose uncontrolled activity causes genomic instability. The piRNA pathway silences transposons in animal gonads, yet how this is achieved molecularly remains controversial. Here, we show that the HMG protein Maelstrom is essential for Piwi-mediated sil...

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Detalhes bibliográficos
Main Authors: Sienski, Grzegorz, Dönertas, Derya, Brennecke, Julius
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504300/
https://ncbi.nlm.nih.gov/pubmed/23159368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.040
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