Mycophenolic Acid Overcomes Imatinib and Nilotinib Resistance of Chronic Myeloid Leukemia Cells by Apoptosis or a Senescent-Like Cell Cycle Arrest

We used K562 cells sensitive or generated resistant to imatinib or nilotinib to investigate their response to mycophenolic acid (MPA). MPA induced DNA damage leading to cell death with a minor contribution of apoptosis, as revealed by annexin V labeling (up to 25%). In contrast, cell cycle arrest an...

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Main Authors: Drullion, Claire, Lagarde, Valérie, Gioia, Romain, Legembre, Patrick, Priault, Muriel, Cardinaud, Bruno, Lippert, Eric, Mahon, François-Xavier, Pasquet, Jean-Max
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504262/
https://ncbi.nlm.nih.gov/pubmed/23213550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/861301
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