Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence

Imatinib, the anti-Abl tyrosine kinase inhibitor used as first-line therapy in chronic myeloid leukemia (CML), eliminates CML cells mainly by apoptosis and induces autophagy. Analysis of imatinib-treated K562 cells reveals a cell population with cell cycle arrest, p27 increase and senescence-associa...

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Detalhes bibliográficos
Main Authors: Drullion, C, Trégoat, C, Lagarde, V, Tan, S, Gioia, R, Priault, M, Djavaheri-Mergny, M, Brisson, A, Auberger, P, Mahon, F-X, Pasquet, J-M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434662/
https://ncbi.nlm.nih.gov/pubmed/22898871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.111
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