The Necrotic Signal Induced by Mycophenolic Acid Overcomes Apoptosis-Resistance in Tumor Cells

BACKGROUND: The amount of inosine monophosphate dehydrogenase (IMPDH), a pivotal enzyme for the biosynthesis of the guanosine tri-phosphate (GTP), is frequently increased in tumor cells. The anti-viral agent ribavirin and the immunosuppressant mycophenolic acid (MPA) are potent inhibitors of IMPDH....

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Bibliographische Detailangaben
Hauptverfasser: Guidicelli, Gwendaline, Chaigne-Delalande, Benjamin, Dilhuydy, Marie-Sarah, Pinson, Benoît, Mahfouf, Walid, Pasquet, Jean-Max, Mahon, François-Xavier, Pourquier, Philippe, Moreau, Jean-François, Legembre, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675064/
https://ncbi.nlm.nih.gov/pubmed/19430526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005493
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