Broad Cross-Presentation of the Hematopoietically-Derived PR1 Antigen on Solid Tumors Leads to Susceptibility to PR1-Targeted Immunotherapy

PR1 is a human leukocyte antigen (HLA)-A2 restricted peptide that has been targeted successfully in myeloid leukemia with immunotherapy. PR1 is derived from the neutrophil granule proteases proteinase 3 (P3) and neutrophil elastase (NE), which are both found in the tumor microenvironment. We recentl...

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Main Authors: Alatrash, Gheath, Mittendorf, Elizabeth A., Sergeeva, Anna, Sukhumalchandra, Pariya, Qiao, Na, Zhang, Mao, St John, Lisa S., Ruisaard, Kathryn, Haugen, Christine E., Al-Atrache, Zein, Jakher, Haroon, Philips, Anne V., Ding, Xiaoling, Chen, Jie Qing, Wu, Yun, Patenia, Rebecca S., Bernatchez, Chantale, Vence, Luis M., Radvanyi, Laszlo G., Hwu, Patrick, Clise-Dwyer, Karen, Ma, Qing, Lu, Sijie, Molldrem, Jeffrey J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504175/
https://ncbi.nlm.nih.gov/pubmed/23105141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201221
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