Activity of 8F4, a T cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo

The PR1 peptide, derived from the leukemia-associated antigens proteinase 3 and neutrophil elastase, is overexpressed on HLA-A2 in acute myeloid leukemia (AML). We developed a high affinity T cell receptor-like murine monoclonal antibody, 8F4, which binds to the PR1/HLA-A2 complex, mediates lysis of...

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Dades bibliogràfiques
Publicat a:Leukemia
Autors principals: Sergeeva, Anna, He, Hong, Ruisaard, Kathryn, St. John, Lisa, Alatrash, Gheath, Clise-Dwyer, Karen, Li, Dan, Patenia, Rebecca, Hong, Richard, Sukhumalchandra, Pariya, You, M. James, Gagea, Mihai, Ma, Qing, Molldrem, Jeffrey J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935597/
https://ncbi.nlm.nih.gov/pubmed/27055866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.57
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