Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621

The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by its ligand, hepatocyte growth factor (HGF), to induce cell growth, motility and morphogenesis. Dysregulation of c-Met function, through mutational activation or overexpression, has been observed in many type...

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Main Authors: Michaud, Neil R., Jani, Jitesh P., Hillerman, Stephen, Tsaparikos, Konstantinos E., Barbacci-Tobin, Elsa G., Knauth, Elisabeth, Putz Jr., Henry, Campbell, Mary, Karam, George A., Chrunyk, Boris, Gebhard, David F., Green, Larry L., Xu, Jinghai J., Dunn, Margaret C., Coskran, Tim M., Lapointe, Jean-Martin, Cohen, Bruce D., Coleman, Kevin G., Bedian, Vahe, Vincent, Patrick, Kajiji, Shama, Steyn, Stefan J., Borzillo, Gary V., Los, Gerrit
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502238/
https://ncbi.nlm.nih.gov/pubmed/23007574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22160
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