Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by (18)F-FDG Small-Animal PET

The purpose of this study was to evaluate the efficacy of CE-355621, a novel antibody against c-Met, in a subcutaneous U87 MG xenograft mouse model using (18)F-FDG small-animal PET. METHODS: CE-355621 or control vehicle was administered intraperitoneally into nude mice (drug-treated group, n = 12; c...

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Main Authors: Tseng, Jeffrey R., Kang, Keon Wook, Dandekar, Mangal, Yaghoubi, Shahriar, Lee, Joseph H., Christensen, James G., Muir, Stephen, Vincent, Patrick W., Michaud, Neil R., Gambhir, Sanjiv S.
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161137/
https://ncbi.nlm.nih.gov/pubmed/18077531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.106.038836
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