Induction of IL-4Rα–dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4–driven murine macrophage proliferation in vivo

Macrophage (MΦ) activation must be tightly controlled to preclude overzealous responses that cause self-damage. MicroRNAs promote classical MΦ activation by blocking antiinflammatory signals and transcription factors but also can prevent excessive TLR signaling. In contrast, the microRNA profile ass...

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Détails bibliographiques
Auteurs principaux: Rückerl, Dominik, Jenkins, Stephen J., Laqtom, Nouf N., Gallagher, Iain J., Sutherland, Tara E., Duncan, Sheelagh, Buck, Amy H., Allen, Judith E.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Phagocytes, Granulocytes, and Myelopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501641/
https://ncbi.nlm.nih.gov/pubmed/22855601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-408252
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