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Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity

Genetic variants of the inhibitory Fc receptor FcγRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown and was investigated by knocking in the most commonly conserved wild mouse...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Espéli, Marion, Clatworthy, Menna R., Bökers, Susanne, Lawlor, Kate E., Cutler, Antony J., Köntgen, Frank, Lyons, Paul A., Smith, Kenneth G.C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Rockefeller University Press 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501356/
https://ncbi.nlm.nih.gov/pubmed/23109709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121752
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