Conservation of Functional Sites on Interleukin-6 and Implications for Evolution of Signaling Complex Assembly and Therapeutic Intervention

A number of secreted cytokines, such as interleukin-6 (IL-6), are attractive targets for the treatment of inflammatory diseases. We have determined the solution structure of mouse IL-6 to assess the functional significance of apparent differences in the receptor interaction sites (IL-6Rα and gp130)...

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Main Authors: Veverka, Vaclav, Baker, Terry, Redpath, Nicholas T., Carrington, Bruce, Muskett, Frederick W., Taylor, Richard J., Lawson, Alastair D. G., Henry, Alistair J., Carr, Mark D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501062/
https://ncbi.nlm.nih.gov/pubmed/23027872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.405597
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