Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES

Interleukin-16 (IL-16) is reported to be a chemoattractant cytokine and modulator of T-cell activation, and has been proposed as a ligand for the co-receptor CD4. The secreted active form of IL-16 has been detected at sites of T(H)1-mediated inflammation, such as those seen in autoimmune diseases, i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hall, Gareth, Cullen, Eilish, Sawmynaden, Kovilen, Arnold, Joanne, Fox, Simon, Cowan, Richard, Muskett, Frederick W., Matthews, David, Merritt, Andrew, Kettleborough, Catherine, Cruikshank, William, Taylor, Debra, Bayliss, Richard, Carr, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974395/
https://ncbi.nlm.nih.gov/pubmed/27231345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709303
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