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Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site
In the cell Mn porphyrins (MnPs) likely couple with cellular reductants which results in a drop of total charge from 5+ to 4+ and dramatically increases their lipophilicity by up to three orders of magnitude depending upon the length of alkylpyridyl chains and type of isomer. The effects result from...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500599/ https://ncbi.nlm.nih.gov/pubmed/20942564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2010.522575 |
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