Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site

In the cell Mn porphyrins (MnPs) likely couple with cellular reductants which results in a drop of total charge from 5+ to 4+ and dramatically increases their lipophilicity by up to three orders of magnitude depending upon the length of alkylpyridyl chains and type of isomer. The effects result from...

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Detalhes bibliográficos
Main Authors: Spasojevic, Ivan, Kos, Ivan, Benov, Ludmil T., Rajic, Zrinka, Fels, Diane, Dedeugd, Casey, Ye, Xiaodong, Vujaskovic, Zeljko, Reboucas, Julio S., Leong, Kam W., Dewhirst, Mark W., Batinic-Haberle, Ines
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500599/
https://ncbi.nlm.nih.gov/pubmed/20942564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2010.522575
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