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Identification and Functional Characterization of a Novel UDP-Glucuronosyltransferase 2A1 Splice Variant: Potential Importance in Tobacco-Related Cancer Susceptibility

UDP-glucuronosyltransferase (UGT) 2A1 is a respiratory and aerodigestive tract-expressing phase II detoxifying enzyme that metabolizes various xenobiotics including polycyclic aromatic hydrocarbons (PAHs). In the present study, a novel exon 3 deletion splice variant was identified for UGT2A1 (UGT2A1...

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Detaylı Bibliyografya
Asıl Yazarlar: Bushey, Ryan T., Lazarus, Philip
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500542/
https://ncbi.nlm.nih.gov/pubmed/22984225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198770
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