Quantification of Hepatic UDP Glucuronosyltransferase 1A Splice Variant Expression and Correlation of UDP Glucuronosyltransferase 1A1 Variant Expression with Glucuronidation Activity

The UDP glucuronosyltransferase (UGT) 1A gene cluster encodes nine UGT1A family members via splicing of individual first exons to common exons 2 through 5. Each of these nine UGT1As can also undergo alternative splicing at their 3′ ends by using an alternate exon 5, resulting in 27 different UGT1A m...

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Main Authors: Jones, Nathan R., Sun, Dongxiao, Freeman, Willard M., Lazarus, Philip
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2012
Ábhair:
Metabolism, Transport, and Pharmacogenomics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422519/
https://ncbi.nlm.nih.gov/pubmed/22661630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.192658
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