Quantification of Hepatic UDP Glucuronosyltransferase 1A Splice Variant Expression and Correlation of UDP Glucuronosyltransferase 1A1 Variant Expression with Glucuronidation Activity

The UDP glucuronosyltransferase (UGT) 1A gene cluster encodes nine UGT1A family members via splicing of individual first exons to common exons 2 through 5. Each of these nine UGT1As can also undergo alternative splicing at their 3′ ends by using an alternate exon 5, resulting in 27 different UGT1A m...

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Bibliographische Detailangaben
Hauptverfasser: Jones, Nathan R., Sun, Dongxiao, Freeman, Willard M., Lazarus, Philip
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2012
Schlagworte:
Metabolism, Transport, and Pharmacogenomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422519/
https://ncbi.nlm.nih.gov/pubmed/22661630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.192658
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