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Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz

Despite combination antiretroviral therapies (cARTs), a significant proportion of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND). Ongoing viral replication in the central nervous system (CNS) caused by poor brain penetration of cART may contribute to HAND. However, it h...

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Main Authors: Tovar-y-Romo, Luis B., Bumpus, Namandjé N., Pomerantz, Daniel, Avery, Lindsay B., Sacktor, Ned, McArthur, Justin C., Haughey, Norman J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2012
Fag:
Toxicology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500535/
https://ncbi.nlm.nih.gov/pubmed/22984227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.195701
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