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Probing a 2-Aminobenzimidazole Library for Binding to RNA Internal Loops via Two-Dimensional Combinatorial Screening

There are many potential RNA drug targets in bacterial, viral, and the human transcriptomes. However, there are few small molecules that modulate RNA function. This is due, in part, to a lack of fundamental understanding about RNA-ligand interactions including the types of small molecules that bind...

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Detalhes bibliográficos
Main Authors: Velegapudi, Sai Pradeep, Pushechnikov, Alexei, Labuda, Lucas P., French, Jonathan M., Disney, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500435/
https://ncbi.nlm.nih.gov/pubmed/22958065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300213g
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