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Comparative chemogenomics to examine the mechanism of action of DNA-targeted platinum-acridine anticancer agents
Platinum-based drugs have been used to successfully treat diverse cancers for several decades. Cisplatin, the original compound of this class, cross-links DNA, resulting in cell cycle arrest and cell death via apoptosis. Cisplatin is effective against several tumor types, yet it exhibits toxic side...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500413/ https://ncbi.nlm.nih.gov/pubmed/22928710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300320d |
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