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Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

Reduced insulin/IGF signaling extends lifespan in diverse species, including Drosophila melanogaster where the genome encodes seven insulin-like peptides (dilp1-7). Of these, reduced dilp2 expressed in the brain has been associated with longevity assurance when over-expression of dfoxo in fat bodies...

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Bibliografski detalji
Glavni autori: Bai, Hua, Kang, Ping, Tatar, Marc
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500397/
https://ncbi.nlm.nih.gov/pubmed/22935001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12000
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