Drosophila insulin‐like peptide dilp1 increases lifespan and glucagon‐like Akh expression epistatic to dilp2

Insulin/IGF signaling (IIS) regulates essential processes including development, metabolism, and aging. The Drosophila genome encodes eight insulin/IGF‐like peptide (dilp) paralogs, including tandem‐encoded dilp1 and dilp2. Many reports show that longevity is increased by manipulations that decrease...

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Bibliografske podrobnosti
izdano v:Aging Cell
Main Authors: Post, Stephanie, Liao, Sifang, Yamamoto, Rochele, Veenstra, Jan A., Nässel, Dick R., Tatar, Marc
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351851/
https://ncbi.nlm.nih.gov/pubmed/30511458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12863
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