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Antagonistic and Cooperative Actions of Kif7 and Sufu Define Graded Intracellular Gli Activities in Hedgehog Signaling

Graded Hedgehog (Hh) signaling governs the balance of Gli transcriptional activators and repressors to specify diverse ventral cell fates in the spinal cord. It remains unclear how distinct intracellular Gli activity is generated. Here, we demonstrate that Sufu acts universally as a negative regulat...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Law, Kelvin King Lo, Makino, Shigeru, Mo, Rong, Zhang, Xiaoyun, Puviindran, Vijitha, Hui, Chi-chung
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500354/
https://ncbi.nlm.nih.gov/pubmed/23166838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050193
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