T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor

Hedgehog signaling is primarily transduced by two transcription factors: Gli2, which mainly acts as a full-length activator, and Gli3, which tends to be proteolytically processed from a full-length form (Gli3(FL)) to an N-terminal repressor (Gli3(REP)). Recent studies using a Sufu knockout mouse hav...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Makino, Shigeru, Zhulyn, Olena, Mo, Rong, Puviindran, Vijitha, Zhang, Xiaoyun, Murata, Takuya, Fukumura, Ryutaro, Ishitsuka, Yuichi, Kotaki, Hayato, Matsumaru, Daisuke, Ishii, Shunsuke, Hui, Chi-Chung, Gondo, Yoichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356511/
https://ncbi.nlm.nih.gov/pubmed/25760946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119455
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