Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

BACKGROUND: Cerebral ischemia has been shown to induce activation of matrix metalloproteinases (MMPs), particularly MMP-9, which is associated with impairment of the neurovasculature, resulting in blood–brain barrier breakdown, hemorrhage and neurodegeneration. We previously reported that the thiira...

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Hauptverfasser: Cui, Jiankun, Chen, Shanyan, Zhang, Chunyang, Meng, Fanjun, Wu, Wei, Hu, Rong, Hadass, Or, Lehmidi, Tareq, Blair, Gregory J, Lee, Mijoon, Chang, Mayland, Mobashery, Shahriar, Sun, Grace Y, Gu, Zezong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500265/
https://ncbi.nlm.nih.gov/pubmed/22587708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-21
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