Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice

Acute ischemic stroke (AIS) is caused by clotting in the cerebral arteries, leading to brain oxygen deprivation and cerebral infarction. Recombinant human tissue plasminogen activator (tPA) is currently the only Food and Drug Administration-approved drug for ischemic stroke. However, tPA has to be a...

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Vydáno v:eNeuro
Hlavní autoři: Chen, Shanyan, Chen, Zhenzhou, Cui, Jiankun, McCrary, Myah L., Song, Hailong, Mobashery, Shahriar, Chang, Mayland, Gu, Zezong
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2018
Témata:
New Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021166/
https://ncbi.nlm.nih.gov/pubmed/29963617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0391-17.2018
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