Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice

Acute ischemic stroke (AIS) is caused by clotting in the cerebral arteries, leading to brain oxygen deprivation and cerebral infarction. Recombinant human tissue plasminogen activator (tPA) is currently the only Food and Drug Administration-approved drug for ischemic stroke. However, tPA has to be a...

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Foilsithe in:eNeuro
Main Authors: Chen, Shanyan, Chen, Zhenzhou, Cui, Jiankun, McCrary, Myah L., Song, Hailong, Mobashery, Shahriar, Chang, Mayland, Gu, Zezong
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2018
Ábhair:
New Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021166/
https://ncbi.nlm.nih.gov/pubmed/29963617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0391-17.2018
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