Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice

Acute ischemic stroke (AIS) is caused by clotting in the cerebral arteries, leading to brain oxygen deprivation and cerebral infarction. Recombinant human tissue plasminogen activator (tPA) is currently the only Food and Drug Administration-approved drug for ischemic stroke. However, tPA has to be a...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Chen, Shanyan, Chen, Zhenzhou, Cui, Jiankun, McCrary, Myah L., Song, Hailong, Mobashery, Shahriar, Chang, Mayland, Gu, Zezong
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021166/
https://ncbi.nlm.nih.gov/pubmed/29963617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0391-17.2018
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