Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice

Acute ischemic stroke (AIS) is caused by clotting in the cerebral arteries, leading to brain oxygen deprivation and cerebral infarction. Recombinant human tissue plasminogen activator (tPA) is currently the only Food and Drug Administration-approved drug for ischemic stroke. However, tPA has to be a...

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Gepubliceerd in:eNeuro
Hoofdauteurs: Chen, Shanyan, Chen, Zhenzhou, Cui, Jiankun, McCrary, Myah L., Song, Hailong, Mobashery, Shahriar, Chang, Mayland, Gu, Zezong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2018
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New Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021166/
https://ncbi.nlm.nih.gov/pubmed/29963617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0391-17.2018
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