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Epigenetic Modification of the Repair Donor Regulates Targeted Gene Correction
Optimizing design of vectors is critical to effective gene therapy. In targeted gene correction (TGC), cleavage of chromosomal DNA near a mutation stimulates homology-directed repair of a target gene using a donor provided in trans. We have systematically addressed epigenetic parameters of donor des...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499697/ https://ncbi.nlm.nih.gov/pubmed/23344649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.42 |
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