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The Dominant Folding Route Minimizes Backbone Distortion in SH3
Energetic frustration in protein folding is minimized by evolution to create a smooth and robust energy landscape. As a result the geometry of the native structure provides key constraints that shape protein folding mechanisms. Chain connectivity in particular has been identified as an essential com...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499259/ https://ncbi.nlm.nih.gov/pubmed/23166485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002776 |
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