Altered Backbone and Side-Chain Interactions Result in Route Heterogeneity during the Folding of Interleukin-1β (IL-1β)

Deletion of the β-bulge trigger-loop results in both a switch in the preferred folding route, from the functional loop packing folding route to barrel closure, as well as conversion of the agonist activity of IL-1β into antagonist activity. Conversely, circular permutations of IL-1β conserve the fun...

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Autors principals: Capraro, Dominique T., Lammert, Heiko, Heidary, David K., Roy, Melinda, Gross, Larry A., Onuchic, José N., Jennings, Patricia A.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
Matèries:
Proteins and Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752112/
https://ncbi.nlm.nih.gov/pubmed/23972849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.06.019
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