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β-Bulge triggers route-switching on the functional landscape of interleukin-1β
Proteins fold into three-dimensional structures in a funneled energy landscape. This landscape is also used for functional activity. Frustration in this landscape can arise from the competing evolutionary pressures of biological function and reliable folding. Thus, the ensemble of partially folded s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277114/ https://ncbi.nlm.nih.gov/pubmed/22307602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114430109 |
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