Folding Circular Permutants of IL-1β: Route Selection Driven by Functional Frustration

Interleukin-1β (IL-1β) is the cytokine crucial to inflammatory and immune response. Two dominant routes are populated in the folding to native structure. These distinct routes are a result of the competition between early packing of the functional loops versus closure of the β-barrel to achieve effi...

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Detaylı Bibliyografya
Asıl Yazarlar: Capraro, Dominique T., Gosavi, Shachi, Roy, Melinda, Onuchic, José N., Jennings, Patricia A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367917/
https://ncbi.nlm.nih.gov/pubmed/22693643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038512
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