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Folding Circular Permutants of IL-1β: Route Selection Driven by Functional Frustration
Interleukin-1β (IL-1β) is the cytokine crucial to inflammatory and immune response. Two dominant routes are populated in the folding to native structure. These distinct routes are a result of the competition between early packing of the functional loops versus closure of the β-barrel to achieve effi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367917/ https://ncbi.nlm.nih.gov/pubmed/22693643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038512 |
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