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Protection from feed-forward amplification in an amplified RNAi mechanism

The effectiveness of RNA interference (RNAi) in many organisms is potentiated through the signal-amplifying activity of a targeted RNA directed RNA polymerase (RdRP) system that can convert a small population of exogenously-encountered dsRNA fragments into an abundant internal pool of small interfer...

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Detalhes bibliográficos
Main Authors: Pak, Julia, Maniar, Jay Mahesh, Mello, Cecilia Cabral, Fire, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499135/
https://ncbi.nlm.nih.gov/pubmed/23141544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.022
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