A feed-forward loop amplifies nutritional regulation of PNPLA3

The upsurge in prevalence of obesity has spawned an epidemic of nonalcoholic fatty liver disease (NAFLD). Previously, we identified a sequence variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that confers susceptibility to both hepatic triglyceride (TG) deposition a...

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Autors principals: Huang, Yongcheng, He, Shaoqing, Li, John Zhong, Seo, Young-Kyo, Osborne, Timothy F., Cohen, Jonathan C., Hobbs, Helen H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867902/
https://ncbi.nlm.nih.gov/pubmed/20385813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003585107
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