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Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease

A genetic variant of PNPLA3 (patatin-like phospholipase domain-containing 3; PNPLA3-I148M), a serine protease of unknown function, is associated with accumulation of triacylglycerol (TAG) in the liver. To determine the biological substrates of PNPLA3 and the effect of the I148M substitution on enzym...

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書誌詳細
主要な著者: Huang, Yongcheng, Cohen, Jonathan C., Hobbs, Helen H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199456/
https://ncbi.nlm.nih.gov/pubmed/21878620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290114
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