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Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease

A genetic variant of PNPLA3 (patatin-like phospholipase domain-containing 3; PNPLA3-I148M), a serine protease of unknown function, is associated with accumulation of triacylglycerol (TAG) in the liver. To determine the biological substrates of PNPLA3 and the effect of the I148M substitution on enzym...

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Bibliografische gegevens
Hoofdauteurs: Huang, Yongcheng, Cohen, Jonathan C., Hobbs, Helen H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199456/
https://ncbi.nlm.nih.gov/pubmed/21878620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290114
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