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Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma

Endogenous RNA-directed RNA polymerases (RdRPs) are cellular components capable of synthesizing new complementary RNAs from existing RNA templates. We present evidence for successive engagement of two different RdRPs in an endogenous siRNA-based mechanism targeting specific mRNAs in C. elegans soma....

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Détails bibliographiques
Auteurs principaux: Gent, Jonathan I., Lamm (Margalit), Ayelet, Pavelec, Derek M., Maniar, Jay M., Parameswaran, Poornima, Tao, Li, Kennedy, Scott, Fire, Andrew Z.
Format: Artigo
Langue:Inglês
Publié: 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838994/
https://ncbi.nlm.nih.gov/pubmed/20116306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.012
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