Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers

Gene promoter hypermethylation is now regarded as a promising biomarker for the risk and progression of lung cancer. The one-carbon metabolism pathway is postulated to affect deoxyribonucleic acid (DNA) methylation because it is responsible for the generation of S-adenosylmethionine (SAM), the methy...

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Detalhes bibliográficos
Main Authors: Flores, Kristina G., Stidley, Christine A., Mackey, Amanda J., Picchi, Maria A., Stabler, Sally P., Siegfried, Jill M., Byers, Tim, Berwick, Marianne, Belinsky, Steven A., Leng, Shuguang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499054/
https://ncbi.nlm.nih.gov/pubmed/22665368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs194
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