Benzo[a]pyrene (BP) DNA adduct formation in DNA repair–deficient p53 haploinsufficient [Xpa(−/−)p53(+/−)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days

We have evaluated DNA damage (DNA adduct formation) after feeding benzo[a]pyrene (BP) to wild-type (WT) and cancer-susceptible Xpa(−/−)p53(+/−) mice deficient in nucleotide excision repair and haploinsufficient for the tumor suppressor p53. DNA damage was evaluated by high-performance liquid chromat...

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Main Authors: John, Kaarthik, Pratt, M.Margaret, Beland, Frederick A., Churchwell, Mona I., McMullen, Gail, Olivero, Ofelia A., Pogribny, Igor P., Poirier, Miriam C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499045/
https://ncbi.nlm.nih.gov/pubmed/22828138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs247
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