Aldehyde dehydrogenase 1A1—a new mediator of resistance to temozolomide in glioblastoma

Implementation of chemotherapy with the drug temozolomide increased the overall survival of patients with glioblastoma multiforme (GBM; WHO grade IV), in particular when the O(6)-methylguanine DNA methyltransferase (MGMT) promoter is epigenetically silenced. Nevertheless, the prognosis remains poor,...

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Hlavní autoři: Schäfer, Andrea, Teufel, Julian, Ringel, Florian, Bettstetter, Marcus, Hoepner, Ingrid, Rasper, Michael, Gempt, Jens, Koeritzer, Julia, Schmidt-Graf, Friederike, Meyer, Bernhard, Beier, Christoph P., Schlegel, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499020/
https://ncbi.nlm.nih.gov/pubmed/23132408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos270
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