CSIG-04. WNT SIGNALING REGULATES ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) TO INDUCE TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA CELLS

Glioma stem cells (GSCs) are considered to be responsible for glioblastoma’s dismal prognosis. The Wingless (WNT) signaling pathway promotes stemness and resistance towards chemo- and radiotherapy in glioblastoma. We have previously shown that pharmacological WNT inhibition using the porcupine inhib...

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Publicado no:Neuro Oncol
Main Authors: Suwala, Abigail K, Koch, Katharina, Deenen, Rene, Köhrer, Karl, Felsberg, Jörg, Reifenberger, Guido, Kahlert, Ulf, Maciaczyk, Jaroslaw
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692671/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.199
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