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Profiling of integral membrane proteins and their post translational modifications using high-resolution mass spectrometry

Integral membrane proteins pose challenges to traditional proteomics approaches due to unique physicochemical properties including hydrophobic transmembrane domains that limit solubility in aqueous solvents. A well resolved intact protein molecular mass profile defines a protein’s native covalent st...

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Autors principals: Souda, Puneet, Ryan, Christopher M., Cramer, William A., Whitelegge, Julian
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498814/
https://ncbi.nlm.nih.gov/pubmed/21982782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2011.09.019
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